All subjects signed informed consent forms. Forty-seven healthy subjects admitted to the Physical Examination Center of Chaohu Hospital affiliated with Anhui Medical University at the same time served as the control group. Materials and methods Research subjectsįorty-two patients with chronic insomnia who visited the Department of General Medicine and Department of Sleep Disorders, Chaohu Hospital Affiliated with Anhui Medical University, from November 2021 to June 2022 were included. To clarify the changes in immunity in patients with chronic insomnia, this article sheds light on the correlation between chronic insomnia and immune function through the detection of CBC, biochemical indicators, lymphocyte subsets, immunoglobulin, complement C3, complement C4, and interleukin-6. However, their relationship is still controversial, and there are few studies on the correlation between chronic insomnia and routine blood tests, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and clinical infection events. Studies have shown that chronic insomnia is related to neutrophils, lymphocyte subsets ( 29), cytokines ( 30), immunoglobulins and complement ( 31). The field bridging insomnia and appeal disease has been defined as neuroimmunology ( 25– 28). Many studies have shown that chronic insomnia can increase the incidence of cardiovascular diseases ( 11– 14), mental diseases ( 15, 16), digestive system diseases ( 17– 20), autoimmune rheumatic diseases ( 21– 24), metabolic syndrome, inflammation, and cancer. There is an inextricable connection between sleep and immunity, in which the activation of the immune system could affect sleep quality, whereas the latter in turn may contribute to the former ( 10). Sleep has been physiologically considered a restorative or recovery phase ( 9). Good sleep feeds back to the immune system, helping the host defend him-/herself to reduce the body's inflammatory response. Inflammation caused by microbial infections that activate the immune system can lead to fatigue and increased sleep desire. It is well known that the relationship between sleep and immunity is bidirectional. Considering that the prevalence of insomnia increases with age, our study selected middle-aged and elderly insomnia patients over 45 years old. The median age of Chinese insomnia patients was 43.7 ( 8). The prevalence of insomnia among the elderly is as high as 60.9% ( 7). The global epidemiological statistics of insomnia range from 10 to 48% ( 2, 3) the incidence of insomnia among females is 1.5 times that among males ( 4) and the incidence of chronic insomnia is gradually increasing in young, middle-aged and elderly people ( 5, 6). The systolic and diastolic blood pressures of the chronic insomnia group did not vary widely from those of the controls ( p > 0.05).Ĭonclusion: Patients with chronic insomnia have immunological abnormalities, characterized by a higher incidence of clinical infection.īy definition, chronic insomnia is used to describe any illness characterized by having trouble falling or staying asleep, waking up earlier than desired, keeping an irregular bedtime, and failing to sleep without the company of parents or others, lasting more than 3 nights a week for 3 months ( 1). Results: There were significant differences in erythrocyte, hemoglobin, hematocrit, albumin, globulin, creatinine, IgG, IgG/IgM ratio, CD4 + T-lymphocytes, CD19-lymphocytes, CD4 +/CD8 + ratio, platelet/lymphocyte ratio, CD19/CD3 ratio, and clinical infection events between the chronic insomnia group and the control group ( p 0.05). Materials and methods: Forty-two patients with chronic insomnia (age = 64.44 ± 10.53) and 47 normal controls (age = 67.08 ± 7.822) were selected to determine differences in data, such as complete blood counts (CBCs), biochemical indices, lymphocyte subsets, immunoglobulin (Ig), complement C3 and C4 and interleukin-6 (IL-6), as well as to compare the incidence of clinical infection between the two groups. Purpose: To investigate the changes in immunity and clinical infection events among patients with chronic insomnia. Department of General Medicine, Chaohu Hospital Affiliated with Anhui Medical University, Chaohu, China.Li Nie † Xian-li Pan † Xiao-bao Zhang Shan Zhang Ji-Xian Rao Zeng-feng Su *
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |